PRB1

Across TCGA cell cohorts, PRB1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRB1-associated genes across cancer lineages are OR1L3, OR56A1, and OR51G2. Each is linked with PRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRB1-to-partner and partner-to-PRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by PRB1-low versus PRB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRB1→partner) and Y-score (partner→PRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	OR56A1 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR51G2 →	+0.066	+4.347	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L3 by PRB1 expression — SKIN

Explore this box plot interactively →