PRAMEF5

Across TCGA patient cohorts, PRAMEF5 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRAMEF5-associated genes across cancer lineages are RNU6-904P, MTND1P26, and NMBR-AS1. Each is linked with PRAMEF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF5-to-partner and partner-to-PRAMEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-904P grouped by PRAMEF5-low versus PRAMEF5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF5→partner) and Y-score (partner→PRAMEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-904P →	+0.546	+6.333	<.001	<.001	3	2
SKCM	MTND1P26 →	+0.092	+4.867	<.001	.005	3	1
SKCM	NMBR-AS1 →	+0.174	+4.513	<.001	.009	3	1
SKCM	RN7SL740P →	+0.245	+4.913	<.001	.002	3	1
SKCM	RN7SL168P →	+0.213	+4.628	<.001	.004	3	1
SKCM	LINC02283 →	+0.125	+5.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

RNU6-904P by PRAMEF5 expression — LUAD

Explore this box plot interactively →