PRAMEF5

Across TCGA cell cohorts, PRAMEF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 94 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PRAMEF5-associated GO terms across cancer lineages are Positive regulation of neuroinflammatory response, Negative regulation of ATP biosynthetic process, and Negative regulation of interleukin-1 production. Each is linked with PRAMEF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF5-to-partner and partner-to-PRAMEF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neuroinflammatory response grouped by PRAMEF5-low versus PRAMEF5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF5→partner) and Y-score (partner→PRAMEF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of neuroinflammatory response →	-0.185	-0.014	.003	.006	3	3
SOFT_TISSUE	Negative regulation of ATP biosynthetic process →	+0.133	+0.085	.001	.007	3	2
SKIN	Negative regulation of interleukin-1 production →	-0.101	-0.015	.002	.004	3	2
SKIN	Negative regulation of platelet-derived growth factor receptor signaling pathway →	+0.135	+0.015	<.001	.004	3	1
SKIN	Carbohydrate biosynthetic process →	+0.070	+0.013	.001	.009	3	1
SKIN	Negative regulation of substrate adhesion-dependent cell spreading →	+0.119	+0.015	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Positive regulation of neuroinflammatory response by PRAMEF5 expression — SKIN

Explore this box plot interactively →