PRAMEF4

Across TCGA patient cohorts, PRAMEF4 mutation is significantly associated with the RNA expression of many other genes, with 1,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF4-associated genes across cancer lineages are MIR875, MIR670, and TEDC2. Each is linked with PRAMEF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF4-to-partner and partner-to-PRAMEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR875 grouped by PRAMEF4-low versus PRAMEF4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF4→partner) and Y-score (partner→PRAMEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR875 →	+0.344	+4.760	.001	.007	3	3
LUSC	MIR670 →	+0.202	+4.578	<.001	.005	3	3
UCEC	TEDC2 →	+0.592	+2.108	.001	.003	3	3
UCEC	UBE2T →	+0.704	+2.627	.001	<.001	3	3
SKCM	KIF22 →	+0.281	+1.765	.004	.003	3	3
LUSC	RNA5SP205 →	+0.157	+4.733	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,946 associations by consensus.

MIR875 by PRAMEF4 expression — BRCA

Explore this box plot interactively →