PRAMEF4

Across TCGA patient cohorts, PRAMEF4 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF4-associated genes across cancer lineages are A-Raf_pS299, Notch1, and TFRC. Each is linked with PRAMEF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF4-to-partner and partner-to-PRAMEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PRAMEF4-low versus PRAMEF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF4→partner) and Y-score (partner→PRAMEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.120	-2.222	.018	.011	3	2
UCEC	Notch1 →	+0.175	+1.750	.003	.049	3	2
UCEC	TFRC →	+0.524	+2.906	.020	.001	3	2
UCEC	Di-Ras3 →	-0.180	-3.308	.004	.009	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.020	.009	3	1
UCEC	EGFR_pY1068 →	-0.329	-2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by PRAMEF4 expression — UCEC

Explore this box plot interactively →