PRAMEF4

Across TCGA cell cohorts, PRAMEF4 RNA expression is significantly associated with the mutation status of many other genes, with 213 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PRAMEF4-associated genes across cancer lineages are PRR14L, JAK1, and CEP295. Each is linked with PRAMEF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF4-to-partner and partner-to-PRAMEF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR14L grouped by PRAMEF4-low versus PRAMEF4-high in URINARY_TRACT.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF4→partner) and Y-score (partner→PRAMEF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRR14L →	+5.044	+0.017	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	JAK1 →	+5.357	+0.186	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	CEP295 →	+4.357	+0.140	.006	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	CDK12 →	+5.357	+0.186	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	GNB2 →	+5.357	+0.186	.003	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	AGFG1 →	+5.357	+0.186	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

PRR14L by PRAMEF4 expression — URINARY_TRACT

Explore this box plot interactively →