PRAMEF33

Across TCGA patient cohorts, PRAMEF33 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRAMEF33-associated genes across cancer lineages are Src, TIGAR, and EGFR. Each is linked with PRAMEF33 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF33-to-partner and partner-to-PRAMEF33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by PRAMEF33-low versus PRAMEF33-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF33→partner) and Y-score (partner→PRAMEF33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.304	-3.000	.021	.036	3	1
SKCM	TIGAR →	+0.149	+3.012	.044	.018	3	1
SKCM	EGFR →	-0.251	-3.000	.007	.036	1	2
SKCM	PTEN →	-0.690	-3.000	.001	.036	2	1
UCEC	Ku80 →	+0.451	+2.820	.001	.036	2	1
SKCM	AMPK_alpha →	+0.251	+3.000	.001	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Src by PRAMEF33 expression — SKCM

Explore this box plot interactively →