PRAMEF33

Across TCGA cell cohorts, PRAMEF33 RNA expression is significantly associated with the mutation status of many other genes, with 260 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRAMEF33-associated genes across cancer lineages are HEATR5B, RPS6KA2, and RFX3. Each is linked with PRAMEF33 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF33-to-partner and partner-to-PRAMEF33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HEATR5B grouped by PRAMEF33-low versus PRAMEF33-high in LUNG_SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF33→partner) and Y-score (partner→PRAMEF33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HEATR5B →	+4.614	+0.392	<.001	<.001	3	2
SKIN	RPS6KA2 →	+4.415	+0.012	.007	<.001	3	2
SKIN	RFX3 →	+5.415	+0.023	.004	<.001	3	2
SKIN	TRIM67 →	+5.415	+0.023	.004	<.001	3	2
SKIN	KLRC1 →	+5.415	+0.023	.004	<.001	3	2
SKIN	XDH →	+2.830	+0.006	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 260 associations by consensus.

HEATR5B by PRAMEF33 expression — LUNG_SCLC

Explore this box plot interactively →