PRAMEF27

Across TCGA patient cohorts, PRAMEF27 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF27-associated genes across cancer lineages are PAI-1, p27_pT157, and S6. Each is linked with PRAMEF27 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF27-to-partner and partner-to-PRAMEF27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by PRAMEF27-low versus PRAMEF27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF27→partner) and Y-score (partner→PRAMEF27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.402	+3.169	.033	.019	3	2
SKCM	p27_pT157 →	-0.138	-2.923	.012	.035	2	2
SKCM	S6 →	-0.551	-3.000	.013	.035	3	1
SKCM	DJ-1 →	+0.242	+3.476	.007	.002	3	1
UCEC	4E-BP1 →	+0.386	+2.837	.009	.035	3	1
UCEC	Tuberin_pT1462 →	+0.303	+2.817	.017	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PAI-1 by PRAMEF27 expression — UCEC

Explore this box plot interactively →