PRAMEF26

Across TCGA cell cohorts, PRAMEF26 mutation is significantly associated with the mutation status of many other genes, with 11 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRAMEF26-associated genes across cancer lineages are TIMP4, RAD54L2, and SMCO2. Each is linked with PRAMEF26 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF26-to-partner and partner-to-PRAMEF26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMP4 grouped by PRAMEF26-low versus PRAMEF26-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF26→partner) and Y-score (partner→PRAMEF26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TIMP4 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	RAD54L2 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	SMCO2 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	KRTAP21-1 →	+5.502	+5.502	.003	.003	1	1
LUNG_SCLC	COL4A6 →	+4.502	+5.066	.007	.007	1	1
LUNG_SCLC	KMT2E →	+4.502	+5.066	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TIMP4 by PRAMEF26 expression — LUNG_SCLC

Explore this box plot interactively →