PRAMEF2

Across TCGA cell cohorts, PRAMEF2 mutation is significantly associated with the mutation status of many other genes, with 826 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRAMEF2-associated genes across cancer lineages are ATP2B3, KIAA0408, and NT5C1B-RDH14. Each is linked with PRAMEF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF2-to-partner and partner-to-PRAMEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP2B3 grouped by PRAMEF2-low versus PRAMEF2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF2→partner) and Y-score (partner→PRAMEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ATP2B3 →	+3.117	+4.491	.004	.004	1	3
BREAST	KIAA0408 →	+4.297	+4.857	.009	.009	1	3
BLOOD_Leukemia	NT5C1B-RDH14 →	+4.736	+5.560	.003	.003	1	3
BREAST	FANCA →	+4.297	+4.857	.009	.009	1	3
BREAST	FPGT-TNNI3K →	+5.297	+5.297	.004	.004	1	3
SKIN	LRRD1 →	+5.824	+5.824	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 826 associations by consensus.

ATP2B3 by PRAMEF2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →