Across TCGA patient cohorts, PRAMEF19 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF19-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and NDRG1_pT346. Each is linked with PRAMEF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF19-to-partner and partner-to-PRAMEF19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF19→partner) and Y-score (partner→PRAMEF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.149	-2.321	.027	.034	3	1
UCEC	mTOR_pS2448 →	-0.143	-1.906	.016	.016	3	1
UCEC	NDRG1_pT346 →	-0.406	-3.169	.039	.018	3	1
UCEC	Notch1 →	+0.179	+2.415	.001	.003	3	1
UCEC	p62 Lck ligand →	+0.328	+1.884	.012	.030	3	1
UCEC	PCNA →	+0.252	+2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PRAMEF19 survival (RNA) · tumor vs normal (RNA) · all PRAMEF19 data types