PRAMEF18

Across TCGA patient cohorts, PRAMEF18 mutation is significantly associated with the RNA expression of many other genes, with 449 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRAMEF18-associated genes across cancer lineages are RNA5SP459, CTBP2P10, and NOD2. Each is linked with PRAMEF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF18-to-partner and partner-to-PRAMEF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP459 grouped by PRAMEF18-low versus PRAMEF18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF18→partner) and Y-score (partner→PRAMEF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP459 →	+0.180	+4.816	<.001	.001	3	2
SKCM	CTBP2P10 →	+0.010	+3.671	<.001	.001	3	2
SKCM	NOD2 →	-0.766	-2.769	.001	.003	3	2
SKCM	MORN4 →	+0.586	+3.719	.001	<.001	3	2
SKCM	CST12P →	+0.043	+3.163	<.001	.001	3	2
SKCM	RPL31P13 →	+0.047	+2.555	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 449 associations by consensus.

RNA5SP459 by PRAMEF18 expression — SKCM

Explore this box plot interactively →