PRAMEF17

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PRAMEF17 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF17-associated genes across cancer lineages are MSH2, Rab25, and Cyclin-B1. Each is linked with PRAMEF17 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF17-to-partner and partner-to-PRAMEF17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF17→partner) and Y-score (partner→PRAMEF17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMSH2 →-0.230-3.433.006.00532
UCECRab25 →-0.375-1.502.002.03032
UCECCyclin-B1 →+0.484+1.502.019.03032
SKCMMEK1_p_S217_S221 →+0.178+1.597.034.04032
UCECEGFR_pY1068 →-0.249-1.807.006.02531
UCECMEK1 →+0.366+2.247.006.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

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