Across TCGA patient cohorts, PRAMEF14 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PRAMEF14-associated genes across cancer lineages are FASN, SF2, and Cyclin-E1. Each is linked with PRAMEF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF14-to-partner and partner-to-PRAMEF14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF14→partner) and Y-score (partner→PRAMEF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.506	+2.178	.005	.035	3	2
COAD	SF2 →	+0.162	+2.178	.013	.035	3	2
COAD	Cyclin-E1 →	+0.321	+3.330	.006	.005	3	2
UCEC	EGFR_pY1068 →	-0.280	-2.000	.013	.032	3	1
UCEC	Notch1 →	+0.185	+3.013	.003	.018	3	1
UCEC	PCNA →	+0.286	+2.000	.003	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PRAMEF14 survival (RNA) · tumor vs normal (RNA) · all PRAMEF14 data types