PRAMEF12

Across TCGA patient cohorts, PRAMEF12 protein abundance is significantly associated with the RNA expression of many other genes, with 1,467 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRAMEF12-associated genes across cancer lineages are APLNR, YPEL1, and MYBL2. Each is linked with PRAMEF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF12-to-partner and partner-to-PRAMEF12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRAMEF12 versus APLNR in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF12→partner) and Y-score (partner→PRAMEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APLNR →	-2.020	-1.125	.001	.004	3	2
GBM	YPEL1 →	+0.669	+1.091	.001	.001	3	1
GBM	MYBL2 →	+1.228	+1.050	<.001	.001	3	1
GBM	SMCHD1 →	+0.525	+1.147	.001	<.001	3	1
GBM	CEP76 →	+0.343	+1.070	.002	.002	3	1
GBM	AMMECR1 →	+0.670	+1.344	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,467 associations by consensus.

PRAMEF12 vs APLNR — GBM

Explore this scatter interactively →