PRAMEF12

Across TCGA cell cohorts, PRAMEF12 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRAMEF12-associated genes across cancer lineages are SLC17A1, UBE2U, and MRGPRG. Each is linked with PRAMEF12 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF12-to-partner and partner-to-PRAMEF12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A1 grouped by PRAMEF12-low versus PRAMEF12-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF12→partner) and Y-score (partner→PRAMEF12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC17A1 →	+0.054	+4.321	<.001	.009	3	1
CNS	UBE2U →	+0.114	+4.472	<.001	.004	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.037	+4.544	<.001	.003	3	1
LUNG_SCLC	OR1L1 →	+0.031	+5.029	.001	.006	3	1
LUNG_SCLC	PRAMEF27 →	+0.020	+5.643	<.001	.002	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.006	+3.099	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC17A1 by PRAMEF12 expression — CNS

Explore this box plot interactively →