Across TCGA patient cohorts, PRAMEF10 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF10-associated genes across cancer lineages are AMPK_alpha, Notch1, and p38-MAPK_pT180_Y182. Each is linked with PRAMEF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF10-to-partner and partner-to-PRAMEF10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF10→partner) and Y-score (partner→PRAMEF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AMPK_alpha →	+0.280	+3.000	<.001	.035	3	2
UCEC	Notch1 →	+0.185	+2.321	.009	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.491	-2.308	.030	.036	3	1
UCEC	ATM →	-0.739	-3.169	.001	.019	3	1
SKCM	GSK-3_pS9 →	-0.641	-3.135	.008	.019	3	1
SKCM	Akt_pS473 →	-0.865	-3.169	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

PRAMEF10 survival (RNA) · tumor vs normal (RNA) · all PRAMEF10 data types