PRAMEF1

Across TCGA patient cohorts, PRAMEF1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,340 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRAMEF1-associated genes across cancer lineages are SYPL2, TAL1, and VEGFD. Each is linked with PRAMEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF1-to-partner and partner-to-PRAMEF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRAMEF1 versus SYPL2 in HNSC, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF1→partner) and Y-score (partner→PRAMEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYPL2 →	-1.721	-0.632	<.001	.001	3	3
GBM	TAL1 →	-0.721	-0.391	<.001	.001	3	3
HNSC	VEGFD →	-1.506	-0.710	.005	.001	3	3
HNSC	SFMBT2 →	-1.159	-0.758	<.001	<.001	3	3
OV	IRAG1 →	-1.200	-0.962	.001	.004	3	3
LSCC	H2AC11 →	+1.072	+0.787	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,340 associations by consensus.

PRAMEF1 vs SYPL2 — HNSC

Explore this scatter interactively →