PRAMEF1

Across TCGA patient cohorts, PRAMEF1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAMEF1-associated genes across cancer lineages are Axl, C-Raf, and FoxM1. Each is linked with PRAMEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF1-to-partner and partner-to-PRAMEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axl grouped by PRAMEF1-low versus PRAMEF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF1→partner) and Y-score (partner→PRAMEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Axl →	+0.526	+1.822	<.001	.013	3	2
SKCM	C-Raf →	+0.131	+1.807	.005	.004	3	2
UCEC	FoxM1 →	+0.245	+2.807	.030	.003	3	2
UCEC	Caspase-8 →	-0.233	-3.584	.034	.002	3	2
SKCM	eIF4G →	+0.338	+3.169	.012	.017	3	1
SKCM	FASN →	-0.380	-1.700	.021	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Axl by PRAMEF1 expression — SKCM

Explore this box plot interactively →