PRAMEF1

Across TCGA cell cohorts, PRAMEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 456 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRAMEF1-associated GO terms across cancer lineages are Regulation of stem cell differentiation, Renal system process, and Alternative mRNA splicing, via spliceosome. Each is linked with PRAMEF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAMEF1-to-partner and partner-to-PRAMEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stem cell differentiation grouped by PRAMEF1-low versus PRAMEF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF1→partner) and Y-score (partner→PRAMEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of stem cell differentiation →	+0.075	+1.733	.001	.002	3	3
BONE	Renal system process →	-0.143	-1.323	<.001	.003	3	3
BONE	Alternative mRNA splicing, via spliceosome →	+0.064	+1.129	.001	.008	3	3
BONE	Purine nucleotide biosynthetic process →	+0.071	+1.286	<.001	.002	3	3
BONE	Mononuclear cell migration →	-0.199	-1.464	.001	.006	3	2
BREAST	Spontaneous synaptic transmission →	+0.641	+0.023	.004	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 456 associations by consensus.

Regulation of stem cell differentiation by PRAMEF1 expression — BONE

Explore this box plot interactively →