PRAMEF1

Across TCGA cell cohorts, PRAMEF1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRAMEF1-associated genes across cancer lineages are XAGE5, SLC10A2, and RHOXF2. Each is linked with PRAMEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAMEF1-to-partner and partner-to-PRAMEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by PRAMEF1-low versus PRAMEF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAMEF1→partner) and Y-score (partner→PRAMEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	XAGE5 →	+1.108	+4.054	<.001	.004	3	2
SKIN	SLC10A2 →	+0.004	+4.437	<.001	.004	3	1
SKIN	RHOXF2 →	+0.083	+3.793	<.001	.007	3	1
SKIN	SSX7 →	+0.032	+3.684	<.001	.006	3	1
SKIN	DEFB135 →	+0.518	+5.000	<.001	<.001	3	1
CNS	TIFAB →	+0.006	+4.981	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

XAGE5 by PRAMEF1 expression — SKIN

Explore this box plot interactively →