Across TCGA patient cohorts, PRAME protein abundance is significantly associated with the RNA expression of many other genes, with 6,912 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRAME-associated genes across cancer lineages are NR4A3, KLHDC9, and RCOR2. Each is linked with PRAME in more than 3 cancer types. Because this analysis shows association rather than direction, both PRAME-to-partner and partner-to-PRAME results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAME→partner) and Y-score (partner→PRAME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NR4A3 →	-0.964	-0.571	.007	.008	2	4
UCEC	KLHDC9 →	+0.880	+0.350	.002	.004	3	3
OV	RCOR2 →	+1.519	+0.660	.003	.002	3	3
OV	DPYD →	-1.675	-0.802	<.001	.002	3	3
OV	NPM1P9 →	+0.703	+0.642	.001	.005	3	3
LSCC	PCYT1B →	+1.351	+1.083	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,912 associations by consensus.

Exploration

PRAME survival (RNA) · tumor vs normal (RNA) · all PRAME data types