Across TCGA patient cohorts, PRAME mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAME-associated genes across cancer lineages are ACC1, 4E-BP1, and eEF2. Each is linked with PRAME in more than 2 cancer types. Because this analysis shows association rather than direction, both PRAME-to-partner and partner-to-PRAME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAME→partner) and Y-score (partner→PRAME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.433	+3.183	.001	.009	3	3
UCEC	4E-BP1 →	+0.337	+2.584	.001	.001	3	3
LUSC	eEF2 →	+0.181	+2.179	.035	.035	3	2
SKCM	MEK1_p_S217_S221 →	+0.227	+2.182	.043	.033	3	2
UCEC	Cyclin-B1 →	+0.490	+3.459	.022	.005	3	2
UCEC	eIF4E →	+0.181	+3.247	.025	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

PRAME survival (RNA) · tumor vs normal (RNA) · all PRAME data types