Across TCGA cell cohorts, PRAME mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRAME-associated genes across cancer lineages are OR4K1, PLA2G3, and TAS2R8. Each is linked with PRAME in more than 1 cancer types. Because this analysis shows association rather than direction, both PRAME-to-partner and partner-to-PRAME results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAME→partner) and Y-score (partner→PRAME) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR4K1 →	+0.029	+5.196	<.001	.005	3	2
LARGE_INTESTINE	PLA2G3 →	+1.942	+3.347	<.001	.005	3	2
CNS	TAS2R8 →	+0.026	+3.201	<.001	.008	3	1
CNS	SMIM9 →	+0.028	+4.754	<.001	<.001	3	1
CNS	ACOT6 →	+0.057	+3.793	.008	.007	3	1
CNS	GAGE12J →	+0.443	+3.321	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

PRAME survival (RNA) · tumor vs normal (RNA) · all PRAME data types