PRAL

Across TCGA pan-cancer cohorts, PRAL RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PRAL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRAL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRAL is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where PRAL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRAL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.216	<.001	12	view →
BLCA	All	All	+0.261	<.001	11	view →
KIRC	Male	All	+0.108	<.001	9	view →
KICH	All	All	−0.066	.001	5	view →
UCEC	All	II,III,IV	−0.203	.012	4	view →
BRCA	All	All	+0.110	.001	4	view →
COAD	Male	All	+0.098	.015	3	view →
STAD	All	All	+0.253	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PRAL–HNSC

Open the HNSC breakdown →