PRAG1

Across TCGA patient cohorts, PRAG1 mutation is significantly associated with the RNA expression of many other genes, with 4,394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAG1-associated genes across cancer lineages are GLRX5, TSR1, and TRMU. Each is linked with PRAG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRAG1-to-partner and partner-to-PRAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRX5 grouped by PRAG1-low versus PRAG1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAG1→partner) and Y-score (partner→PRAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GLRX5 →	+0.467	+3.359	<.001	.004	3	4
STAD	TSR1 →	+0.615	+3.186	<.001	.009	3	4
UCEC	TRMU →	+0.481	+3.279	<.001	<.001	3	4
STAD	ERI1 →	+0.699	+2.651	<.001	.005	2	5
UCEC	PTS →	+0.307	+2.828	.004	.001	3	4
SKCM	DONSON →	+0.464	+2.434	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,394 associations by consensus.

GLRX5 by PRAG1 expression — STAD

Explore this box plot interactively →