PRAG1

Across TCGA patient cohorts, PRAG1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRAG1-associated genes across cancer lineages are Caspase-7-cleavedD198, ETS-1, and mTOR_pS2448. Each is linked with PRAG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRAG1-to-partner and partner-to-PRAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRAG1-low versus PRAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAG1→partner) and Y-score (partner→PRAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.614	+1.697	.001	.012	3	4
UCEC	ETS-1 →	+0.212	+1.584	.047	.009	3	3
UCEC	mTOR_pS2448 →	-0.164	-2.489	<.001	.001	3	3
UCEC	ATM →	-0.427	-1.687	.004	.040	3	3
UCEC	Bak →	+0.210	+1.807	.012	.024	3	3
UCEC	AR →	-0.329	-1.874	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by PRAG1 expression — UCEC

Explore this box plot interactively →