PRAG1

Across TCGA cell cohorts, PRAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,895 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRAG1-associated GO terms across cancer lineages are Regulation of actin filament polymerization, Negative regulation of supramolecular fiber organization, and Regulation of cellular component size. Each is linked with PRAG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PRAG1-to-partner and partner-to-PRAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of actin filament polymerization grouped by PRAG1-low versus PRAG1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAG1→partner) and Y-score (partner→PRAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of actin filament polymerization →	+0.089	+1.658	<.001	<.001	3	13
PANCREAS	Negative regulation of supramolecular fiber organization →	+0.080	+1.369	.003	.003	3	12
PANCREAS	Regulation of cellular component size →	+0.058	+1.296	<.001	<.001	3	12
SKIN	Positive regulation of plasma membrane repair →	+0.123	+1.187	<.001	.001	3	12
BONE	Rho protein signal transduction →	+0.118	+2.070	.004	.001	3	11
LARGE_INTESTINE	Regulation of actin polymerization or depolymerization →	+0.083	+1.638	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,895 associations by consensus.

Regulation of actin filament polymerization by PRAG1 expression — URINARY_TRACT

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