PRAF2

Across TCGA cell cohorts, PRAF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,343 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PRAF2-associated GO terms across cancer lineages are Growth hormone secretion, Positive regulation of type 2 mitophagy, and Cell communication involved in cardiac conduction. Each is linked with PRAF2 in more than 12 cancer types. Because this analysis shows association rather than direction, both PRAF2-to-partner and partner-to-PRAF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone secretion grouped by PRAF2-low versus PRAF2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRAF2→partner) and Y-score (partner→PRAF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Growth hormone secretion →	+0.150	+2.157	<.001	<.001	3	13
STOMACH	Positive regulation of type 2 mitophagy →	+0.155	+2.324	<.001	<.001	3	12
OESOPHAGUS	Cell communication involved in cardiac conduction →	-0.238	-1.670	<.001	.002	3	12
STOMACH	Negative regulation of endodermal cell differentiation →	+1.221	+1.735	<.001	<.001	3	11
SKIN	Fatty acid oxidation →	+0.043	+1.054	.001	.003	3	11
KIDNEY	Eosinophil activation involved in immune response →	+0.199	+1.338	<.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,343 associations by consensus.

Growth hormone secretion by PRAF2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →