PQBP1

Across TCGA pan-cancer cohorts, PQBP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PQBP1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PQBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PQBP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

HNSC, COAD, and LUAD are the cancer types where PQBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.683	0.890	.001	62	view →
COAD	DFS	Median	All	1.000	0.893	.029	36	view →
LUAD	OS	Tertile	II,III,IV	0.877	0.471	.003	24	view →
CCRCC	OS	Median	All	0.888	1.000	.003	12	view →
UCEC	DFS	Median	All	1.000	0.936	.023	2	view →
GBM	DFS	Tertile	All	0.439	0.303	.049	2	view →
LSCC	OS	Median	II,III,IV	1.000	0.892	.035	2	view →
PDAC	DFS	Tertile	All	0.591	0.384	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PQBP1–HNSC (DFS)

Open the HNSC breakdown →