PQBP1

Across TCGA patient cohorts, PQBP1 mutation is significantly associated with the RNA expression of many other genes, with 2,629 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PQBP1-associated genes across cancer lineages are RNA5SP467, PCGF5, and AZI2. Each is linked with PQBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PQBP1-to-partner and partner-to-PQBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP467 grouped by PQBP1-low versus PQBP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PQBP1→partner) and Y-score (partner→PQBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP467 →	+0.246	+5.539	<.001	.004	3	2
UCEC	PCGF5 →	+0.361	+2.080	.003	<.001	3	2
UCEC	AZI2 →	+0.460	+2.288	<.001	<.001	3	2
UCEC	ANKMY2 →	+0.452	+2.787	<.001	<.001	3	2
UCEC	AVPI1 →	+0.456	+1.798	.003	.007	3	2
STAD	RNU1-57P →	+0.620	+5.611	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,629 associations by consensus.

RNA5SP467 by PQBP1 expression — CESC

Explore this box plot interactively →