PQBP1

Across TCGA patient cohorts, PQBP1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PQBP1-associated genes across cancer lineages are GATA6, Shc_pY317, and EGFR_pY1068. Each is linked with PQBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PQBP1-to-partner and partner-to-PQBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by PQBP1-low versus PQBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PQBP1→partner) and Y-score (partner→PQBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.134	-1.700	.027	.042	3	2
UCEC	Shc_pY317 →	-0.148	-1.807	.006	.025	3	2
UCEC	EGFR_pY1068 →	-0.190	-1.584	.035	.019	3	1
UCEC	ERK2 →	+0.161	+1.906	.020	.015	3	1
UCEC	JNK_pT183_Y185 →	-0.139	-2.000	.022	.030	3	1
UCEC	JNK2 →	+0.195	+1.925	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GATA6 by PQBP1 expression — UCEC

Explore this box plot interactively →