PPY2P

Across TCGA pan-cancer cohorts, PPY2P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PPY2P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PPY2P RNA is repressed in tumor relative to normal tissue. In most cancer types PPY2P is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where PPY2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPY2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.273	<.001	9	view →
KIRC	Male	II,III,IV	−0.269	<.001	9	view →
HNSC	Male	III,IV	+0.131	.019	8	view →
UCEC	All	All	+0.480	<.001	6	view →
THCA	Male	II,III,IV	−0.155	<.001	6	view →
KICH	All	All	−0.324	<.001	5	view →
LUAD	All	All	+0.315	.001	4	view →
BRCA	All	All	+0.109	.002	4	view →
BLCA	All	All	+0.488	.047	2	view →
COAD	All	II,III,IV	+0.024	.035	2	view →
LUSC	All	All	+0.211	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PPY2P–KIRP

Open the KIRP breakdown →