PPY

Across TCGA patient cohorts, PPY protein abundance is significantly associated with the RNA expression of many other genes, with 700 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PPY-associated genes across cancer lineages are SLC8A3, MYLK2, and CDH20. Each is linked with PPY in more than 1 cancer types. Because this analysis shows association rather than direction, both PPY-to-partner and partner-to-PPY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PPY versus SLC8A3 in PDAC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPY→partner) and Y-score (partner→PPY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC8A3 →	+0.314	+1.458	<.001	<.001	3	1
PDAC	MYLK2 →	+0.568	+0.900	.003	<.001	3	1
PDAC	CDH20 →	+0.169	+0.859	.009	.006	3	1
PDAC	PCSK1N →	+0.828	+1.109	.009	.001	3	1
PDAC	DHRS12 →	+0.221	+0.878	.001	.005	3	1
PDAC	NOMO3 →	+0.399	+1.005	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 700 associations by consensus.

PPY vs SLC8A3 — PDAC

Explore this scatter interactively →