PPY

Across TCGA cell cohorts, PPY RNA expression is significantly associated with the go_rna of many other GO terms, with 745 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PPY-associated GO terms across cancer lineages are Cellular pigmentation, Reelin-mediated signaling pathway, and Regulation of ovarian follicle development. Each is linked with PPY in more than 4 cancer types. Because this analysis shows association rather than direction, both PPY-to-partner and partner-to-PPY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular pigmentation grouped by PPY-low versus PPY-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPY→partner) and Y-score (partner→PPY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cellular pigmentation →	+0.047	+0.076	<.001	<.001	3	5
KIDNEY	Reelin-mediated signaling pathway →	+0.140	+0.040	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of ovarian follicle development →	+0.118	+0.064	.006	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	Sensory perception of mechanical stimulus →	-0.046	-0.070	.006	.007	3	3
CNS	Response to thyroid hormone →	+0.068	+0.052	.004	.003	3	3
BLOOD_Leukemia	Negative regulation of epithelial cell differentiation involved in kidney development →	+0.160	+0.041	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 745 associations by consensus.

Cellular pigmentation by PPY expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →