PPWD1

Across TCGA pan-cancer cohorts, PPWD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPWD1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPWD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPWD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where PPWD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.901	0.367	.011	14	view →
PDAC	DFS	Tertile	IV	0.934	0.235	.024	9	view →
HNSC	OS	Median	All	1.000	0.961	.031	3	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.489	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPWD1–LUAD (DFS)

Open the LUAD breakdown →