PPWD1

Across TCGA patient cohorts, PPWD1 mutation is significantly associated with the RNA expression of many other genes, with 1,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPWD1-associated genes across cancer lineages are OR5F1, RBMY2AP, and MIR6761. Each is linked with PPWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPWD1-to-partner and partner-to-PPWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5F1 grouped by PPWD1-low versus PPWD1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPWD1→partner) and Y-score (partner→PPWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5F1 →	+0.069	+7.930	<.001	.008	3	2
LUAD	RBMY2AP →	+0.059	+7.930	<.001	.008	3	2
SKCM	MIR6761 →	+0.533	+5.867	<.001	.003	3	1
UCEC	ESS2 →	+0.317	+2.010	<.001	.001	3	1
UCEC	GGA1 →	+0.299	+2.413	.004	<.001	3	1
UCEC	HIRA →	+0.440	+2.021	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

OR5F1 by PPWD1 expression — LUAD

Explore this box plot interactively →