PPWD1

Across TCGA patient cohorts, PPWD1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPWD1-associated genes across cancer lineages are Akt_pT308, eEF2, and A-Raf_pS299. Each is linked with PPWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPWD1-to-partner and partner-to-PPWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PPWD1-low versus PPWD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPWD1→partner) and Y-score (partner→PPWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.651	+3.321	.012	.009	3	2
UCEC	eEF2 →	+0.304	+3.169	.039	.018	3	1
UCEC	A-Raf_pS299 →	-0.117	-1.807	.017	.027	3	1
UCEC	ERK2 →	+0.234	+3.700	.003	.001	3	1
UCEC	GAPDH →	+0.508	+2.321	.021	.033	3	1
UCEC	ACC1 →	+0.317	+2.321	.035	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Akt_pT308 by PPWD1 expression — UCEC

Explore this box plot interactively →