PPWD1

Across TCGA cell cohorts, PPWD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,960 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPWD1-associated GO terms across cancer lineages are Centrosome duplication, mRNA splice site recognition, and Regulation of sister chromatid cohesion. Each is linked with PPWD1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PPWD1-to-partner and partner-to-PPWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome duplication grouped by PPWD1-low versus PPWD1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPWD1→partner) and Y-score (partner→PPWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Centrosome duplication →	+0.119	+1.003	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.124	+0.810	<.001	<.001	3	17
BLOOD_Myeloma	Regulation of sister chromatid cohesion →	+0.132	+0.918	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.085	+1.081	.002	<.001	3	17
OVARY	Nucleotide-excision repair →	+0.057	+0.740	<.001	<.001	3	16
URINARY_TRACT	DNA recombination →	+0.065	+0.955	.004	.003	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,960 associations by consensus.

Centrosome duplication by PPWD1 expression — LUNG_SCLC

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