PPRC1

Across TCGA pan-cancer cohorts, PPRC1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PPRC1 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPRC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPRC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, OV, and SCLC are the cancer types where PPRC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.122	0.685	.001	33	view →
OV	OS	Median	II,III,IV	0.505	0.844	.009	24	view →
SCLC	DFS	Median	II,III,IV	0.192	0.585	.002	24	view →
BLCA	OS	Median	III,IV	0.090	0.582	<.001	9	view →
LUSC	OS	Median	III,IV	0.140	0.683	.034	6	view →
UCEC	DFS	Median	II,III,IV	0.838	0.434	.042	6	view →
SARC	DFS	Median	All	0.006	0.591	<.001	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PPRC1–HNSC (DFS)

Open the HNSC breakdown →