PPRC1

Across TCGA patient cohorts, PPRC1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPRC1-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and Shc_pY317. Each is linked with PPRC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPRC1-to-partner and partner-to-PPRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PPRC1-low versus PPRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPRC1→partner) and Y-score (partner→PPRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.099	-1.489	.023	.025	3	4
UCEC	eIF4E →	+0.160	+2.169	.009	.003	3	3
UCEC	Shc_pY317 →	-0.129	-1.736	.003	.006	3	3
COAD	Caspase-7-cleavedD198 →	+1.162	+2.708	<.001	.003	3	3
SKCM	PEA-15 →	+0.176	+2.000	.003	.029	3	3
COAD	14-3-3_beta →	-0.178	-1.974	.032	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

mTOR_pS2448 by PPRC1 expression — UCEC

Explore this box plot interactively →