PPRC1

Across TCGA cell cohorts, PPRC1 mutation is significantly associated with the RNA expression of many other genes, with 743 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPRC1-associated genes across cancer lineages are OR1P1, TTC19, and PKDREJ. Each is linked with PPRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPRC1-to-partner and partner-to-PPRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1P1 grouped by PPRC1-low versus PPRC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPRC1→partner) and Y-score (partner→PPRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1P1 →	+0.030	+4.887	.002	.009	3	2
BLOOD_Leukemia	TTC19 →	+0.447	+3.115	.009	.009	3	2
BLOOD_Leukemia	PKDREJ →	+0.290	+2.733	.005	.002	3	2
BLOOD_Leukemia	MFSD9 →	+0.545	+2.614	.001	.003	3	2
BLOOD_Leukemia	PEX5 →	+1.031	+3.730	<.001	<.001	3	2
BLOOD_Leukemia	CDR2 →	+1.005	+3.503	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 743 associations by consensus.

OR1P1 by PPRC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →