PPP6R3

Across TCGA pan-cancer cohorts, PPP6R3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP6R3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP6R3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP6R3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where PPP6R3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	1.000	0.327	.009	16	view →
LSCC	DFS	Tertile	III,IV	0.439	1.000	.007	12	view →
HNSC	OS	Tertile	All	0.949	0.844	.026	4	view →
LUAD	OS	Quartile	III,IV	1.000	0.261	.037	3	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
GBM	OS	Quartile	All	0.715	0.947	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP6R3–UCEC (OS)

Open the UCEC breakdown →