PPP6R3

Across TCGA patient cohorts, PPP6R3 mutation is significantly associated with the RNA expression of many other genes, with 3,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R3-associated genes across cancer lineages are GOT1, ELAC1, and SARS1. Each is linked with PPP6R3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP6R3-to-partner and partner-to-PPP6R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by PPP6R3-low versus PPP6R3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R3→partner) and Y-score (partner→PPP6R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GOT1 →	+0.586	+3.616	.001	.001	3	3
SKCM	ELAC1 →	+0.462	+3.208	.004	.009	3	3
SKCM	SARS1 →	+0.596	+3.218	<.001	.009	3	3
UCEC	CABCOCO1 →	-0.882	-2.726	<.001	<.001	3	3
UCEC	MYO19 →	+0.419	+2.266	<.001	<.001	3	3
COAD	HINT2 →	+0.383	+3.381	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,189 associations by consensus.

GOT1 by PPP6R3 expression — SKCM

Explore this box plot interactively →