PPP6R3

Across TCGA patient cohorts, PPP6R3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R3-associated genes across cancer lineages are PKC-b-II_pS660, eIF4E, and GAPDH. Each is linked with PPP6R3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP6R3-to-partner and partner-to-PPP6R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by PPP6R3-low versus PPP6R3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R3→partner) and Y-score (partner→PPP6R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-b-II_pS660 →	-0.550	-3.576	<.001	.002	3	3
UCEC	eIF4E →	+0.185	+2.598	.002	<.001	3	2
UCEC	GAPDH →	+0.376	+1.765	.017	.011	3	2
UCEC	p62 Lck ligand →	+0.233	+1.450	.014	.014	3	2
UCEC	STAT3_pY705 →	-0.274	-1.352	<.001	.034	3	2
UCEC	ATM →	-0.634	-2.099	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-b-II_pS660 by PPP6R3 expression — COAD

Explore this box plot interactively →