PPP6R3

Across TCGA cell cohorts, PPP6R3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,089 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP6R3-associated GO terms across cancer lineages are Heterochromatin organization, Heterochromatin formation, and Regulation of DNA repair. Each is linked with PPP6R3 in more than 17 cancer types. Because this analysis shows association rather than direction, both PPP6R3-to-partner and partner-to-PPP6R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by PPP6R3-low versus PPP6R3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R3→partner) and Y-score (partner→PPP6R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Heterochromatin organization →	+0.092	+0.977	.002	.002	3	18
BONE	Heterochromatin formation →	+0.099	+1.108	.001	<.001	3	18
SOFT_TISSUE	Regulation of DNA repair →	+0.071	+0.979	<.001	<.001	3	17
BONE	Negative regulation of cell cycle process →	+0.091	+0.676	.004	.004	3	17
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome →	+0.082	+0.792	.003	.009	3	17
BONE	Epigenetic regulation of gene expression →	+0.079	+0.795	<.001	.004	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,089 associations by consensus.

Heterochromatin organization by PPP6R3 expression — BONE

Explore this box plot interactively →