PPP6R3

Across TCGA cell cohorts, PPP6R3 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP6R3-associated genes across cancer lineages are POTEB3, GPR101, and FHL5. Each is linked with PPP6R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP6R3-to-partner and partner-to-PPP6R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB3 grouped by PPP6R3-low versus PPP6R3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R3→partner) and Y-score (partner→PPP6R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POTEB3 →	+0.036	+4.432	<.001	.003	3	2
BLOOD_Leukemia	GPR101 →	+0.106	+3.551	<.001	.009	3	2
BLOOD_Myeloma	FHL5 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MBL2 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPATA19 →	+0.033	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR6B3 →	+0.020	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

POTEB3 by PPP6R3 expression — STOMACH

Explore this box plot interactively →