PPP6R2

Across TCGA pan-cancer cohorts, PPP6R2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP6R2 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP6R2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP6R2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PPP6R2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.885	0.575	<.001	51	view →
HNSC	OS	Median	All	1.000	0.344	.009	35	view →
LSCC	DFS	Median	III,IV	0.429	0.871	.007	21	view →
LUAD	OS	Quartile	II,III,IV	0.505	0.927	.010	9	view →
GBM	OS	Quartile	All	1.000	0.807	.013	7	view →
PDAC	OS	Tertile	IV	0.472	0.962	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP6R2–CCRCC (DFS)

Open the CCRCC breakdown →