PPP6R2

Across TCGA patient cohorts, PPP6R2 RNA expression is significantly associated with the mutation status of many other genes, with 8,379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP6R2-associated genes across cancer lineages are MCF2L2, TBX18, and DNAH8. Each is linked with PPP6R2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP6R2-to-partner and partner-to-PPP6R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCF2L2 grouped by PPP6R2-low versus PPP6R2-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP6R2→partner) and Y-score (partner→PPP6R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCF2L2 →	+3.137	+0.305	<.001	<.001	3	4
UCEC	TBX18 →	+2.928	+0.278	<.001	.005	3	4
UCEC	DNAH8 →	+1.516	+0.218	<.001	.001	3	4
UCEC	ARHGEF6 →	+2.343	+0.241	<.001	.004	3	4
COAD	ADGRD1 →	+4.141	+0.349	<.001	.002	3	3
COAD	SIPA1L2 →	+3.847	+0.392	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,379 associations by consensus.

MCF2L2 by PPP6R2 expression — UCEC

Explore this box plot interactively →